Publications

  1. Morsut, L, Quadrato, G. Guiding human development in a dish. Nat. Methods. 2019;16 (7):585-586. doi: 10.1038/s41592-019-0464-1. PubMed PMID:31249404 .
  2. Velasco, S, Kedaigle, AJ, Simmons, SK, Nash, A, Rocha, M, Quadrato, G et al.. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. 2019;570 (7762):523-527. doi: 10.1038/s41586-019-1289-x. PubMed PMID:31168097 .
  3. Brown, J, Quadrato, G, Arlotta, P. Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. Curr. Top. Dev. Biol. 2018;129 :99-122. doi: 10.1016/bs.ctdb.2018.03.002. PubMed PMID:29801532 .
  4. Quadrato, G, Arlotta, P. Present and future of modeling human brain development in 3D organoids. Curr. Opin. Cell Biol. 2017;49 :47-52. doi: 10.1016/j.ceb.2017.11.010. PubMed PMID:29227864 .
  5. Quadrato, G, Nguyen, T, Macosko, EZ, Sherwood, JL, Min Yang, S, Berger, DR et al.. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545 (7652):48-53. doi: 10.1038/nature22047. PubMed PMID:28445462 PubMed Central PMC5659341.
  6. Quadrato, G, Brown, J, Arlotta, P. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat. Med. 2016;22 (11):1220-1228. doi: 10.1038/nm.4214. PubMed PMID:27783065 .
  7. Quadrato, G, Zhang, AC, Arlotta, P. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016;18 (3):297-9. doi: 10.1016/j.stem.2016.02.008. PubMed PMID:26942845 .
  8. Joshi, Y, Sória, MG, Quadrato, G, Inak, G, Zhou, L, Hervera, A et al.. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015;138 (Pt 7):1843-62. doi: 10.1093/brain/awv125. PubMed PMID:25981963 .
  9. Ottone, C, Krusche, B, Whitby, A, Clements, M, Quadrato, G, Pitulescu, ME et al.. Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat. Cell Biol. 2014;16 (11):1045-56. doi: 10.1038/ncb3045. PubMed PMID:25283993 PubMed Central PMC4298702.
  10. Quadrato, G, Elnaggar, MY, Duman, C, Sabino, A, Forsberg, K, Di Giovanni, S et al.. Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4. J. Neurosci. 2014;34 (25):8630-45. doi: 10.1523/JNEUROSCI.0047-14.2014. PubMed PMID:24948817 PubMed Central PMC6608211.
  11. Quadrato, G, Elnaggar, MY, Di Giovanni, S. Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement. Front Neurosci. 2014;8 :17. doi: 10.3389/fnins.2014.00017. PubMed PMID:24574955 PubMed Central PMC3921569.
  12. Forsberg, K, Wuttke, A, Quadrato, G, Chumakov, PM, Wizenmann, A, Di Giovanni, S et al.. The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J. Neurosci. 2013;33 (36):14318-30. doi: 10.1523/JNEUROSCI.1056-13.2013. PubMed PMID:24005285 PubMed Central PMC6618388.
  13. Quadrato, G, Di Giovanni, S. Gatekeeper between quiescence and differentiation: p53 in axonal outgrowth and neurogenesis. Int. Rev. Neurobiol. 2012;105 :71-89. doi: 10.1016/B978-0-12-398309-1.00005-6. PubMed PMID:23206596 .
  14. Floriddia, EM, Rathore, KI, Tedeschi, A, Quadrato, G, Wuttke, A, Lueckmann, JM et al.. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. J. Neurosci. 2012;32 (40):13956-70. doi: 10.1523/JNEUROSCI.1925-12.2012. PubMed PMID:23035104 PubMed Central PMC6704782.
  15. Quadrato, G, Di Giovanni, S. Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis. Cell. Mol. Life Sci. 2013;70 (6):993-1007. doi: 10.1007/s00018-012-1099-x. PubMed PMID:22899311 .
  16. Ferreira, LM, Floriddia, EM, Quadrato, G, Di Giovanni, S. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol. Neurobiol. 2012;46 (2):227-41. doi: 10.1007/s12035-012-8290-9. PubMed PMID:22717989 .
  17. Quadrato, G, Benevento, M, Alber, S, Jacob, C, Floriddia, EM, Nguyen, T et al.. Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc. Natl. Acad. Sci. U.S.A. 2012;109 (23):E1499-508. doi: 10.1073/pnas.1202068109. PubMed PMID:22586092 PubMed Central PMC3384134.
  18. Denis-Donini, S, Dellarole, A, Crociara, P, Francese, MT, Bortolotto, V, Quadrato, G et al.. Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice. J. Neurosci. 2008;28 (15):3911-9. doi: 10.1523/JNEUROSCI.0148-08.2008. PubMed PMID:18400889 PubMed Central PMC6670458.