Publications

  1. He, Z, Dony, L, Fleck, JS, Szałata, A, Li, KX, Slišković, I et al.. An integrated transcriptomic cell atlas of human neural organoids. Nature. 2024;635 (8039):690-698. doi: 10.1038/s41586-024-08172-8. PubMed PMID:39567792 .
  2. Santorelli, M, Bhamidipati, PS, Courte, J, Swedlund, B, Jain, N, Poon, K et al.. Control of spatio-temporal patterning via cell growth in a multicellular synthetic gene circuit. Nat Commun. 2024;15 (1):9867. doi: 10.1038/s41467-024-53078-8. PubMed PMID:39562554 .
  3. Chung, CS, Kou, Y, Shemtov, SJ, Verheijen, BM, Flores, I, Love, K et al.. Transcript errors generate amyloid-like proteins in huwman cells. Nat Commun. 2024;15 (1):8676. doi: 10.1038/s41467-024-52886-2. PubMed PMID:39375347 PubMed Central PMC11458900.
  4. Atamian, A, Birtele, M, Hosseini, N, Nguyen, T, Seth, A, Del Dosso, A et al.. Human cerebellar organoids with functional Purkinje cells. Cell Stem Cell. 2024;31 (1):39-51.e6. doi: 10.1016/j.stem.2023.11.013. PubMed PMID:38181749 PubMed Central PMC11417151.
  5. Birtele, M, Del Dosso, A, Xu, T, Nguyen, T, Wilkinson, B, Hosseini, N et al.. Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis. Nat Neurosci. 2023;26 (12):2090-2103. doi: 10.1038/s41593-023-01477-3. PubMed PMID:37946050 PubMed Central PMC11349286.
  6. Urenda, JP, Del Dosso, A, Birtele, M, Quadrato, G. Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids. Biol Psychiatry. 2023;93 (7):606-615. doi: 10.1016/j.biopsych.2022.12.017. PubMed PMID:36759258 PubMed Central PMC11229385.
  7. Cable, J, Lutolf, MP, Fu, J, Park, SE, Apostolou, A, Chen, S et al.. Organoids as tools for fundamental discovery and translation-a Keystone Symposia report. Ann N Y Acad Sci. 2022;1518 (1):196-208. doi: 10.1111/nyas.14874. PubMed PMID:36177906 PubMed Central PMC11293861.
  8. Atamian, A, Birtele, M, Quadrato, G. Not all cortical organoids are created equal. Nat Cell Biol. 2022;24 (6):805-806. doi: 10.1038/s41556-022-00890-3. PubMed PMID:35697780 PubMed Central PMC11216691.
  9. Paulsen, B, Velasco, S, Kedaigle, AJ, Pigoni, M, Quadrato, G, Deo, AJ et al.. Autism genes converge on asynchronous development of shared neuron classes. Nature. 2022;602 (7896):268-273. doi: 10.1038/s41586-021-04358-6. PubMed PMID:35110736 PubMed Central PMC8852827.
  10. Del Dosso, A, Urenda, JP, Nguyen, T, Quadrato, G. Upgrading the Physiological Relevance of Human Brain Organoids. Neuron. 2020;107 (6):1014-1028. doi: 10.1016/j.neuron.2020.08.029. PubMed PMID:32970996 PubMed Central PMC10042151.
  11. Atamian, A, Cordón-Barris, L, Quadrato, G. Taming human brain organoids one cell at a time. Semin Cell Dev Biol. 2021;111 :23-31. doi: 10.1016/j.semcdb.2020.05.022. PubMed PMID:32718852 PubMed Central PMC11268727.
  12. Morsut, L, Quadrato, G. Guiding human development in a dish. Nat Methods. 2019;16 (7):585-586. doi: 10.1038/s41592-019-0464-1. PubMed PMID:31249404 .
  13. Velasco, S, Kedaigle, AJ, Simmons, SK, Nash, A, Rocha, M, Quadrato, G et al.. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. 2019;570 (7762):523-527. doi: 10.1038/s41586-019-1289-x. PubMed PMID:31168097 PubMed Central PMC6906116.
  14. Brown, J, Quadrato, G, Arlotta, P. Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. Curr Top Dev Biol. 2018;129 :99-122. doi: 10.1016/bs.ctdb.2018.03.002. PubMed PMID:29801532 .
  15. Quadrato, G, Arlotta, P. Present and future of modeling human brain development in 3D organoids. Curr Opin Cell Biol. 2017;49 :47-52. doi: 10.1016/j.ceb.2017.11.010. PubMed PMID:29227864 .
  16. Quadrato, G, Nguyen, T, Macosko, EZ, Sherwood, JL, Min Yang, S, Berger, DR et al.. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017;545 (7652):48-53. doi: 10.1038/nature22047. PubMed PMID:28445462 PubMed Central PMC5659341.
  17. Quadrato, G, Brown, J, Arlotta, P. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016;22 (11):1220-1228. doi: 10.1038/nm.4214. PubMed PMID:27783065 .
  18. Quadrato, G, Zhang, AC, Arlotta, P. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016;18 (3):297-9. doi: 10.1016/j.stem.2016.02.008. PubMed PMID:26942845 .
  19. Joshi, Y, Sória, MG, Quadrato, G, Inak, G, Zhou, L, Hervera, A et al.. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015;138 (Pt 7):1843-62. doi: 10.1093/brain/awv125. PubMed PMID:25981963 .
  20. Ottone, C, Krusche, B, Whitby, A, Clements, M, Quadrato, G, Pitulescu, ME et al.. Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat Cell Biol. 2014;16 (11):1045-56. doi: 10.1038/ncb3045. PubMed PMID:25283993 PubMed Central PMC4298702.
  21. Quadrato, G, Elnaggar, MY, Duman, C, Sabino, A, Forsberg, K, Di Giovanni, S et al.. Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4. J Neurosci. 2014;34 (25):8630-45. doi: 10.1523/JNEUROSCI.0047-14.2014. PubMed PMID:24948817 PubMed Central PMC6608211.
  22. Quadrato, G, Elnaggar, MY, Di Giovanni, S. Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement. Front Neurosci. 2014;8 :17. doi: 10.3389/fnins.2014.00017. PubMed PMID:24574955 PubMed Central PMC3921569.
  23. Forsberg, K, Wuttke, A, Quadrato, G, Chumakov, PM, Wizenmann, A, Di Giovanni, S et al.. The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J Neurosci. 2013;33 (36):14318-30. doi: 10.1523/JNEUROSCI.1056-13.2013. PubMed PMID:24005285 PubMed Central PMC6618388.
  24. Quadrato, G, Di Giovanni, S. Gatekeeper between quiescence and differentiation: p53 in axonal outgrowth and neurogenesis. Int Rev Neurobiol. 2012;105 :71-89. doi: 10.1016/B978-0-12-398309-1.00005-6. PubMed PMID:23206596 .
  25. Floriddia, EM, Rathore, KI, Tedeschi, A, Quadrato, G, Wuttke, A, Lueckmann, JM et al.. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. J Neurosci. 2012;32 (40):13956-70. doi: 10.1523/JNEUROSCI.1925-12.2012. PubMed PMID:23035104 PubMed Central PMC6704782.
  26. Quadrato, G, Di Giovanni, S. Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis. Cell Mol Life Sci. 2013;70 (6):993-1007. doi: 10.1007/s00018-012-1099-x. PubMed PMID:22899311 PubMed Central PMC11113138.
  27. Ferreira, LM, Floriddia, EM, Quadrato, G, Di Giovanni, S. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol Neurobiol. 2012;46 (2):227-41. doi: 10.1007/s12035-012-8290-9. PubMed PMID:22717989 .
  28. Quadrato, G, Benevento, M, Alber, S, Jacob, C, Floriddia, EM, Nguyen, T et al.. Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci U S A. 2012;109 (23):E1499-508. doi: 10.1073/pnas.1202068109. PubMed PMID:22586092 PubMed Central PMC3384134.
  29. Denis-Donini, S, Dellarole, A, Crociara, P, Francese, MT, Bortolotto, V, Quadrato, G et al.. Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice. J Neurosci. 2008;28 (15):3911-9. doi: 10.1523/JNEUROSCI.0148-08.2008. PubMed PMID:18400889 PubMed Central PMC6670458.